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1

Editorial title: Lessons learned from a “failed” clinical trial

Leijten, E.F. A, Radstake, T.R.D.J., Reedquist, K.A.

Journal:

Arthritis & Rheumatology

Année:

2018

Langue:

english

Fichier:

PDF, 494 KB

english, 2018

2

Activation of the Ras-related GTPase Rap1 by thymocyte TCR engagement and during selection

Derk Amsen, Ada Kruisbeek, Johannes L. Bos, Kris Reedquist

Journal:

European Journal of Immunology

Année:

2000

Langue:

english

Fichier:

PDF, 170 KB

english, 2000

3

Intracellular free radical production in synovial T lymphocytes from patients with rheumatoid arthritis

P. H. J. Remans, M. van Oosterhout, T. J. M. Smeets, M. Sanders, W. M. Frederiks, K. A. Reedquist, P. P. Tak, F. C. Breedveld, J. M. van Laar

Journal:

Arthritis & Rheumatism

Année:

2005

Langue:

english

Fichier:

PDF, 265 KB

english, 2005

4

CTLA-4IG suppresses reactive oxygen species by preventing synovial adherent cell–induced inactivation of rap1, a ras family GTPASE mediator of oxidative stress in rheumatoid arthritis T cells

P. H. J. Remans, C. A. Wijbrandts, M. E. Sanders, R. E. Toes, F. C. Breedveld, P. P. Tak, J. M. van Laar, K. A. Reedquist

Journal:

Arthritis & Rheumatism

Année:

2006

Langue:

english

Fichier:

PDF, 289 KB

english, 2006

5

Inhibition of forkhead box class O family member transcription factors in rheumatoid synovial tissue

J. Ludikhuize, D. de Launay, D. Groot, T. J. M. Smeets, M. Vinkenoog, M. E. Sanders, S. W. Tas, P. P. Tak, K. A. Reedquist

Journal:

Arthritis & Rheumatism

Année:

2007

Langue:

english

Fichier:

PDF, 1.38 MB

english, 2007

6

Tumor necrosis factor α drives cadherin 11 expression in rheumatoid inflammation

Bernard Vandooren, Tineke Cantaert, Mariëtte Ter Borg, Troy Noordenbos, Rodger Kuhlman, Daniëlle Gerlag, Tim Bongartz, Kris Reedquist, Paul P. Tak, Dominique Baeten

Journal:

Arthritis & Rheumatism

Année:

2008

Langue:

english

Fichier:

PDF, 323 KB

english, 2008

7

Deletion of either CD55 or CD97 ameliorates arthritis in mouse models

Robert M. Hoek, Daphne de Launay, Else N. Kop, A. Seda Yilmaz-Elis, Feng Lin, Kris A. Reedquist, J. Sjef Verbeek, M. Edward Medof, Paul P. Tak, Jörg Hamann

Journal:

Arthritis & Rheumatism

Année:

2010

Langue:

english

Fichier:

PDF, 134 KB

english, 2010

8

Sustained T cell Rap1 signaling is protective in the collagen-induced arthritis model of rheumatoid arthritis

Joana R. F. Abreu, Sarah Krausz, Wendy Dontje, Aleksander M. Grabiec, Daphne de Launay, Martijn A. Nolte, Paul P. Tak, Kris A. Reedquist

Journal:

Arthritis & Rheumatism

Année:

2010

Langue:

english

Fichier:

PDF, 547 KB

english, 2010

9

Differential expression of transcription factors predicted to regulate angiopoietin-1 and -2 genes is associated with specific angiopoietin signatures in RA and PsA synovial tissue

M Frleta, LGM van Baarsen, S Garcia-Perez, D de Launay, M Garrelfs, DM Gerlag, PP Tak, KA Reedquist

Journal:

Pediatric Rheumatology

Année:

2011

Langue:

english

Fichier:

PDF, 90 KB

english, 2011

10

Apoptosis induced by overall metabolic stress converges on the Bcl-2 family proteins Noxa and Mcl-1

Felix M. Wensveen, Nuno L. Alves, Ingrid A. M. Derks, Kris A. Reedquist, Eric Eldering

Journal:

Année:

2011

Langue:

english

Fichier:

PDF, 897 KB

english, 2011

11

RAP1 SIGNALLING: ADHERING TO NEW MODELS

Bos, Johannes L., de Rooij, Johan, Reedquist, Kris A.

Journal:

Nature Reviews Molecular Cell Biology

Année:

2001

Langue:

english

Fichier:

PDF, 711 KB

english, 2001

12

Stimulation through the T cell receptor leads to interactions between SHB and several signaling proteins

Welsh, Michael, Songyang, Zhou, Frantz, J Daniel, Trüb, Thomas, Reedquist, Kris A, Karlsson, Torbjörn, Miyazaki, Masaya, Cantley, Lewis C, Band, Hamid, Shoelson, Steven E

Journal:

Année:

1998

Langue:

english

Fichier:

PDF, 485 KB

english, 1998

13

Angiopoietin-2 promotes inflammatory activation of human macrophages and is essential for murine experimental arthritis

Krausz, S., Garcia, S., Ambarus, C. A., de Launay, D., Foster, M., Naiman, B., Iverson, W., Connor, J. R., Sleeman, M. A., Coyle, A. J., Hamann, J., Baeten, D., Tak, P. P., Reedquist, K. A.

Journal:

Annals of the Rheumatic Diseases

Année:

2012

Langue:

english

Fichier:

PDF, 2.56 MB

english, 2012

14

Brief Report: A phase IIa, randomized, double-blind, placebo-controlled trial of apilimod mesylate, an interleukin-12/interleukin-23 inhibitor, in patients with rheumatoid arthritis

Sarah Krausz, Maria J. H. Boumans, Danielle M. Gerlag, Joelle Lufkin, Arno W. R. van Kuijk, Alian Bakker, Maarten de Boer, Beatrijs M. Lodde, Kris A. Reedquist, Eric W. Jacobson, Michael O'Meara, Paul

Journal:

Arthritis & Rheumatism

Année:

2012

Langue:

english

Fichier:

PDF, 361 KB

english, 2012

15

Inflammatory memories: Is epigenetics the missing link to persistent stromal cell activation in rheumatoid arthritis?

Caroline Ospelt, Kris A. Reedquist, Steffen Gay, Paul P. Tak

Journal:

Autoimmunity Reviews

Année:

2011

Langue:

english

Fichier:

PDF, 322 KB

english, 2011

16

Systematic validation of specific phenotypic markers for in vitro polarized human macrophages

C.A. Ambarus, S. Krausz, M. van Eijk, J. Hamann, T.R.D.J. Radstake, K.A. Reedquist, P.P. Tak, D.L.P. Baeten

Journal:

Journal of Immunological Methods

Année:

2012

Langue:

english

Fichier:

PDF, 678 KB

english, 2012

17

Lovastatin Inhibits Proliferation and Differentiation and Causes Apoptosis in Lipopolysaccharide-Stimulated Murine B Cells

K.A. Reedquist, T.K. Pope, D.A. Roess

Journal:

Biochemical and Biophysical Research Communications

Année:

1995

Fichier:

PDF, 299 KB

1995

18

NGF-Dependent Neurite Outgrowth in PC12 Cells Overexpressing the Src Homology 2-Domain Protein Shb Requires Activation of the Rap1 Pathway

Lingge Lu, Cecilia Annerén, Kris A. Reedquist, Johannes L. Bos, Michael Welsh

Journal:

Experimental Cell Research

Année:

2000

Langue:

english

Fichier:

PDF, 309 KB

english, 2000

19

In search of a function for the Ras-like GTPase Rap1

Johannes L Bos, Barbara Franke, Laura M'Rabet, Kris Reedquist, Fried Zwartkruis

Journal:

Année:

1997

Langue:

english

Fichier:

PDF, 400 KB

english, 1997

20

Sustained Rap1 activation in autoantigen-specific T lymphocytes attenuates experimental autoimmune encephalomyelitis

Salinas, Gabriela Franco, Krausz, Sarah, Dontje, Wendy, Evavold, Brian D., Tak, Paul P., Baeten, Dominique L., Reedquist, Kris A.

Journal:

Journal of Neuroimmunology

Année:

2012

Langue:

english

Fichier:

PDF, 1.03 MB

english, 2012

21

Shear Stress-Dependent Downregulation of the Adhesion-G Protein-Coupled Receptor CD97 on Circulating Leukocytes upon Contact with Its Ligand CD55

Karpus, O. N., Veninga, H., Hoek, R. M., Flierman, D., van Buul, J. D., vandenAkker, C. C., vanBavel, E., Medof, M. E., van Lier, R. A. W., Reedquist, K. A., Hamann, J.

Journal:

The Journal of Immunology

Année:

2013

Langue:

english

Fichier:

PDF, 1.00 MB

english, 2013

22

Targeting histone deacetylase activity in rheumatoid arthritis and asthma as prototypes of inflammatory disease: should we keep our HATs on?

Aleksander M Grabiec, Paul P Tak, Kris A Reedquist

Journal:

Arthritis Research & Therapy

Année:

2008

Langue:

english

Fichier:

PDF, 921 KB

english, 2008

23

Histone deacetylases in RA: epigenetics and epiphenomena

Aleksander M Grabiec, Kris A Reedquist

Journal:

Arthritis Research & Therapy

Année:

2010

Langue:

english

Fichier:

PDF, 128 KB

english, 2010

24

Specific contributions of H-Ras and N-Ras GTPases to T-lymphocyte oxidative stress and integrin-dependent retention in rheumatoid arthritis

PHJ Remans, ME Sanders, PP Tak, KA Reedquist

Journal:

Arthritis Research & Therapy

Année:

2005

Langue:

english

Fichier:

PDF, 1.61 MB

english, 2005

25

Synovial monocytes mediate Rap1-dependent oxidative stress in rheumatoid arthritis T lymphocytes

PH Remans, JM van Laar, ME Sanders, P-P Tak, KA Reedquist

Journal:

Arthritis Research & Therapy

Année:

2005

Langue:

english

Fichier:

PDF, 1.61 MB

english, 2005

26

Treatment with recombinant interferon-β reduces inflammation and slows cartilage destruction in the collagen-induced arthritis model of rheumatoid arthritis

Judith van Holten, Kris Reedquist, Pascale Sattonet-Roche…

Journal:

Arthritis Research & Therapy

Année:

2004

Langue:

english

Fichier:

PDF, 1.73 MB

english, 2004

27

The effects of NF-κB inhibition by a NEMO binding domain peptidein vitroandin vivo

SW Tas, EC de Jong, MJ Vervoordeldonk, KA Reedquist, M May, S Ghosh…

Journal:

Arthritis Research & Therapy

Année:

2004

Langue:

english

Fichier:

PDF, 527 KB

english, 2004

28

IFN-β for the treatment of rheumatoid arthritis?

P Tak, van J Holten, K Reedquist, P Sattonet-Roche, T Smeets…

Journal:

Arthritis Research & Therapy

Année:

2003

Langue:

english

Fichier:

PDF, 554 KB

english, 2003

29

Constitutively activated N-Ras stimulates LFA-1-dependent adhesion in rheumatoid arthritis synovial fluid T lymphocytes

KA Reedquist, PHJ Remans, SI Gringhuis, KMT de Bruyn, S Rangarajan, JL Bos…

Journal:

Arthritis Research & Therapy

Année:

2002

Langue:

english

Fichier:

PDF, 808 KB

english, 2002

30

Deregulated Ras and Rap1 signaling in rheumatoid arthritis T cells leads to persistent production of free radicals

PHJ Remans, KA Reedquist, JL Bos, CL Verweij, FC Breedveld, JM van Laar…

Journal:

Arthritis Research & Therapy

Année:

2002

Langue:

english

Fichier:

PDF, 808 KB

english, 2002

31

Defective Rap1 activation in synovial fluid T cells from patients with rheumatoid arthritis

PHJ Remans, SI Gringhuis, K Reedquist, FC Breedveld, JM van Laar…

Journal:

Arthritis Research & Therapy

Année:

2001

Langue:

english

Fichier:

PDF, 430 KB

english, 2001

32

Histone deacetylase inhibitors suppress rheumatoid arthritis fibroblast-like synoviocyte and macrophage IL-6 production by accelerating mRNA decay

Grabiec, A. M., Korchynskyi, O., Tak, P. P., Reedquist, K. A.

Journal:

Annals of the Rheumatic Diseases

Année:

2012

Langue:

english

Fichier:

PDF, 416 KB

english, 2012

33

TOF-Secondary Ion Mass Spectrometry Imaging of Polymeric Scaffolds with Surrounding Tissue after in Vivo Implantation

Klerk, Leendert A., Dankers, Patricia Y. W., Popa, Eliane R., Bosman, Anton W., Sanders, Marjolein E., Reedquist, Kris A., Heeren, Ron M. A.

Journal:

Analytical Chemistry

Année:

2010

Langue:

english

Fichier:

PDF, 3.71 MB

english, 2010

34

Functional interactions between PI3-kinase and NF- B signaling pathways promote joint destruction in rheumatoid arthritis

Hartkamp, L. M., Grabiec, A. M., Ludikhuize, J., van Es, I. E., Sanders, M. E., Tak, P. P., Reedquist, K. A.

Journal:

Annals of the Rheumatic Diseases

Année:

2011

Langue:

english

Fichier:

PDF, 78 KB

english, 2011

35

The bromodomain protein inhibitor I-BET151 suppresses expression of inflammatory genes and matrix degrading enzymes in rheumatoid arthritis synovial fibroblasts

Klein, K., Kabala, P. A., Grabiec, A. M., Gay, R. E., Kolling, C., Lin, L.-L., Gay, S., Tak, P. P., Prinjha, R. K., Ospelt, C., Reedquist, K. A.

Journal:

Annals of the Rheumatic Diseases

Année:

2014

Langue:

english

Fichier:

PDF, 2.98 MB

english, 2014

36

Inflammatory cytokines epigenetically regulate rheumatoid arthritis fibroblast-like synoviocyte activation by suppressing HDAC5 expression

Angiolilli, C., Grabiec, A. M., Ferguson, B. S., Ospelt, C., Malvar Fernandez, B., van Es, I. E., van Baarsen, L. G. M., Gay, S., McKinsey, T. A., Tak, P. P., Baeten, D. L., Reedquist, K. A.

Journal:

Annals of the Rheumatic Diseases

Année:

2014

Langue:

english

Fichier:

PDF, 9.26 MB

english, 2014

37

Inhibiting epigenetic enzymes to improve atherogenic macrophage functions

Van den Bossche, Jan, Neele, Annette E., Hoeksema, Marten A., de Heij, Femke, Boshuizen, Marieke C.S., van der Velden, Saskia, de Boer, Vincent C., Reedquist, Kris A., de Winther, Menno P.J.

Journal:

Biochemical and Biophysical Research Communications

Année:

2014

Langue:

english

Fichier:

PDF, 1.41 MB

english, 2014

38

The rheumatoid arthritis synovial microenvironment promotes differentiation of monocytes into pro-angiogenic macrophages responsive to angiopoietin signaling

Perez, S. G., Krausz, S., Ambarus, C. A., Baeten, D. L., Peter, P. P. T. P., Reedquist, K. A.

Journal:

Annals of the Rheumatic Diseases

Année:

2012

Langue:

english

Fichier:

PDF, 80 KB

english, 2012

39

Btk inhibition suppresses agonist-induced human macrophage activation and inflammatory gene expression in RA synovial tissue explants

Hartkamp, Linda M, Fine, Jay S, van Es, Inge E, Tang, Man Wai, Smith, Michael, Woods, John, Narula, Satwant, DeMartino, Julie, Tak, Paul P, Reedquist, Kris A

Journal:

Annals of the Rheumatic Diseases

Année:

2015

Langue:

english

Fichier:

PDF, 3.09 MB

english, 2015

40

TWEAK and its receptor Fn14 in the synovium of patients with rheumatoid arthritis compared to psoriatic arthritis and its response to tumour necrosis factor blockade

van Kuijk, A W R, Wijbrandts, C A, Vinkenoog, M, Zheng, T S, Reedquist, K A, Tak, P P

Journal:

Annals of the Rheumatic Diseases

Année:

2010

Langue:

english

Fichier:

PDF, 1.48 MB

english, 2010

41

The ascent of acetylation in the epigenetics of rheumatoid arthritis

Grabiec, Aleksander M., Reedquist, Kris A.

Journal:

Nature Reviews Rheumatology (formerly Nature Clinical Practice Rheumatology)

Année:

2013

Langue:

english

Fichier:

PDF, 433 KB

english, 2013

42

JNK-dependent downregulation of FoxO1 is required to promote the survival of fibroblast-like synoviocytes in rheumatoid arthritis

Grabiec, A. M., Angiolilli, C., Hartkamp, L. M., van Baarsen, L. G. M., Tak, P. P., Reedquist, K. A.

Journal:

Annals of the Rheumatic Diseases

Année:

2014

Langue:

english

Fichier:

PDF, 2.94 MB

english, 2014

43

Signaling through CD70 Regulates B Cell Activation and IgG Production

Arens, R., Nolte, M. A., Tesselaar, K., Heemskerk, B., Reedquist, K. A., van Lier, R. A. W., van Oers, M. H. J.

Journal:

The Journal of Immunology

Année:

2004

Langue:

english

Fichier:

PDF, 405 KB

english, 2004

44

A Novel Phosphotyrosine-binding Domain in the N-terminal Transforming Region of Cbl Interacts Directly and Selectively with ZAP-70 in T Cells

Reedquist, K. A.

Journal:

Journal of Biological Chemistry

Année:

1996

Langue:

english

Fichier:

PDF, 905 KB

english, 1996

45

The Presumed Hyporesponsive Behavior of Rheumatoid Arthritis T Lymphocytes Can Be Attributed to Spontaneous Ex Vivo Apoptosis rather than Defects in T Cell Receptor Signaling

Abreu, J. R. F., Grabiec, A. M., Krausz, S., Spijker, R., Burakowski, T., Maslinski, W., Eldering, E., Tak, P. P., Reedquist, K. A.

Journal:

The Journal of Immunology

Année:

2009

Langue:

english

Fichier:

PDF, 3.01 MB

english, 2009

46

T Cell Activation-dependent Association between the p85 Subunit of the Phosphatidylinositol 3-Kinase and Grb2/Phospholipase C- 1-binding Phosphotyrosyl Protein pp36/38

Fukazawa, T., Reedquist, K. A., Panchamoorthy, G., Soltoff, S., Trub, T., Druker, B., Cantley, L., Shoelson, S. E., Band, H.

Journal:

Journal of Biological Chemistry

Année:

1995

Fichier:

PDF, 8.32 MB

1995

47

Tangiopoietins-1 and -2 are differentially regulated and make distinct contributions to synovial Tie2 activation in patients with rheumatoid arthritis and psoriatic arthritis

Frleta, M., van Baarsen, L. G. M., de Launay, D., Garrelfs, M., Gerlag, D. M., Tak, P. P., Reedquist, K. A.

Journal:

Annals of the Rheumatic Diseases

Année:

2011

Langue:

english

Fichier:

PDF, 79 KB

english, 2011

48

Costimulation through CD28 Suppresses T Cell Receptor-dependent Activation of the Ras-like Small GTPase Rap1 in Human T Lymphocytes

Reedquist, K. A.

Journal:

Journal of Biological Chemistry

Année:

1998

Langue:

english

Fichier:

PDF, 655 KB

english, 1998

49

Constitutively active Rap1 protects from experimental autoimmune encephalomyelitis (EAE) by quantitative and qualitative modulation of auto-reactive T cells

Franco, S. G., Krausz, S., Dontje, W., Tak, P., Baeten, D., Reedquist, K.

Journal:

Annals of the Rheumatic Diseases

Année:

2011

Langue:

english

Fichier:

PDF, 86 KB

english, 2011

50

Silencing expression of Ras family GTPase homologues decreases inflammation and joint destruction in experimental arthritis

de Launay, D, Vreijling, J, Abreu, J R F, van Maanen, M A, Sanders, M E, Vervoordeldonk, M J, Oerum, H, Fluiter, K, Tak, P P, Reedquist, K A

Journal:

Annals of the Rheumatic Diseases

Année:

2010

Langue:

english

Fichier:

PDF, 70 KB

english, 2010